BioDMET History of Changes
BioDMET version 2.0
Released: September 8, 2010
- Implemented novel critically-ill patient analysis functionality and database.
- Implemented dialog to input liver clearance rates based on alternative methods (e.g. half-life of parent molecule).
- Implemented ability to quickly update multiple rows (concentrations, units, selection) for Enzyme and Pathogen tables.
- Added functionality to update body mass and BMI when changing gender on wizards and dialogs.
- Moved Agent on the model view tree from Administer to Element tree nodes.
- Update model view tree to show connections between injection and molecule.
- Improved the 'Estimated' time to complete sensitivity analysis.
- Default values for adding extra administrations is now generated.
- Software now automatically expands Agent model tree view when opening model file.
- Fixed issue of being able to create a Pathogen Instance for a Host Cell.
- Fixed issue were Molecule property table was not updated properly when right (popup menu) mouse clicking on item.
- Fixed issue were PK property table was not updated properly when user edits the sampling times.
- The 'Add menu items' within the 'Model' menu are now not displayed when they are disabled due to context of selection.
- Now using 'subcutaneous' to represent 'intradermal' administrations.
BioDMET version 1.6
Released: June 28, 2010
- Implemented two new Pharmacodynamic (PD) functions for modeling pathogen-drug interactions.
- Implemented PD function for potential inoculum effect (e.g. slower killing of bacteria at high bacterial densities).
- Implemented ability to model different pathogen growth rates at distinct locations and tissue fluids.
- Updated default liver clearance location to the interstitial space around liver cells.
- Fixed issue when using large Hill Coefficients for drug-pathogen PD equation.
- Fixed the issue when attempting to copy multiple rows from the property tables.
- Improved compute time performance by 30-40% for a simulation run.
BioDMET version 1.5
Released: May 5, 2010
- Ability to display computed PK parameters for time concentration curve and simple compartment model fits.
- Ability to vary one or all parameters in Monte Carlo analysis for parameter sensitivity analysis.
- Added summary plots and pdf report generation for parameter sensitivity analysis.
- Fixed problem with not all jar library files being properly signed.
BioDMET version 1.4
Released: March 2, 2010
- Added capability to perform parameter sensitivity analysis.
- Ability to run Monte Carlo analysis to the determine impact of parameter variance on end point variance.
- Ability to run one- and two-at-a-time parameter change analysis.
- Fixed problem with delay in initial simulation runs.
- Fixed unit labels for Transporters and Biotransformation reactions.
BioDMET version 1.3
Released: February 9, 2010
- Ability to customize export of model data for use by 3rd party software.
- Optimized performance on web hosting site.
- Ability to export numbers in scientific notation.
- Changed units used to store the max and min growth rate, was (min-1) now is(log(CFU/ml)/min)
- Updated the default dosage from 0.1 to 10.0
- Fixed problem in application when user tried to delete a fluid space.
BioDMET version 1.2
Released: January 5, 2010
- Improved plotting capability.
- Ability to zoom in/out of plot data.
- Copy plots to clipboard and save plots to a file.
- Ability to generate comparison plots that display concentration over time at multiple locations.
BioDMET version 1.1
Released: November 19, 2009
- Implemented 2nd generation model for enzymes (transporters, biotransformation, receptors).
- Ability to import and export enzymes as model fragments.
BioDMET version 1.0
Released: October 1, 2009
- Database of healthy host physiological parameters for human, rhesus monkey, guinea pig, rat, and mouse.
- Database of pathogen-host physiological parameters.
- Database of of PBPK model validation test data.
- Graphical user interface for the BioDMET software tool.
- Implemented Pharmacodynamic functionality (1st generation) to model antibiotic and antiviral effects.
Copyright © 2009-2013 General Electric Corp. All rights reserved.
|Model and tool development funded by GE and
Defense Threat Reduction Agency Contract No. HDTRA-08-C-0052