BioDMET Validation

Summary of prediction accuracy

Comparing the calculated vs. measured concentration of all drug/agents in human, rat, and mouse. The blue triangle symbols represent plasma drug concentrations and the red square symbols represent tissue (muscle, heart, lung, liver, kidney, intestine, stomach, bone, brain, spleen, skin, adipose) drug concentrations.

The references and details for the model test cases used to generate the summary plot are provided in a PDF document. (Note: the size of this PDF file is approximately 2MB.)

Testing across species

Mouse, Rat, Monkey measurements from Kita, Y., T. Yamazaki, et al. (1992). "Comparative pharmacokinetics of SCE-2787 and related antibiotics in experimental animals." Antimicrob Agents Chemother 36(11): 2481-6.

Human measurements from Paulfeuerborn, W., H. J. Muller, et al. (1993). "Comparative pharmacokinetics and serum bactericidal activities of SCE-2787 and ceftazidime." Antimicrob Agents Chemother 37(9): 1835-41.

Sathirakul, K., H. Suzuki, et al. (1994). "Multiple transport systems for organic anions across the bile canalicular membrane." J Pharmacol Exp Ther 268(1): 65-73.

Testing in various human tissues

Measurements from Muller, M., O. Haag, et al. (1996). "Characterization of peripheral-compartment kinetics of antibiotics by in vivo microdialysis in humans." Antimicrob Agents Chemother 40(12): 2703-9.

Testing under different physiological conditions

Measurements from Gaspari, F., N. Perico, et al. (1995). "Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate." J Am Soc Nephrol 6(2): 257-63.

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Model and tool development funded by GE and
Defense Threat Reduction Agency Contract No. HDTRA-08-C-0052